论文标题
蛋白质结构预测直到CASP15
Protein Structure Prediction until CASP15
论文作者
论文摘要
在2020年12月，Alphafold2的结果在CASP14上呈现，在蛋白质结构预测领域引发了一场革命。纯计算方法首次可以挑战单蛋白结构域的结构预测实验精度。 Alphafold2的代码于2021年夏季发布，从那时起，可以使用它来准确预测大多数（有序）蛋白质和许多蛋白质蛋白质相互作用的结构。它还引发了该领域发展的爆炸，改善了基于AI的方法来预测蛋白质复合物，无序区域和蛋白质设计。在这里，我将回顾Alphafold发行引发的一些发明。
In Dec 2020, the results of AlphaFold2 were presented at CASP14, sparking a revolution in the field of protein structure predictions. For the first time, a purely computational method could challenge experimental accuracy for structure prediction of single protein domains. The code of AlphaFold2 was released in the summer of 2021, and since then, it has been shown that it can be used to accurately predict the structure of most (ordered) proteins and many protein-protein interactions. It has also sparked an explosion of development in the field, improving AI-based methods to predict protein complexes, disordered regions, and protein design. Here I will review some of the inventions sparked by the release of AlphaFold.
