论文标题

用于开发$^{225} $基于AC的放射性药物的编码光圈和康普顿成像

Coded Aperture and Compton Imaging for the Development of $^{225}$Ac-based Radiopharmaceuticals

论文作者

Frame, Emily A., Bobba, Kondapa N., Gunter, Donald L., Mihailescu, Lucian, Bidkar, Anil P., Flavell, Robert R., Vetter, Kai

论文摘要

靶向α-粒子疗法(TAT)作为癌症治疗具有很大的希望。可以说,提出的最有前途的tat radionuclide是$^{225} $ ac。由于缺乏有效的手段来研究这些药物在临床前阶段,这些药物在小动物中研究这些药物的女儿重新分布,因此$^{225} $基于AC的放射性药物的发展受到了阻碍。直接成像女儿的能力,即$^{221} $ fr和$^{213} $ bi,通过其伽马射线排放将是临床前研究的福音。也就是说,由于灵敏度限制,无法采用常规的医学成像方式,包括基于针孔准直的单光子发射计算机断层扫描(SPECT)。作为替代方案,我们提出了使用编码的光圈和康普顿成像的使用,并以前的模式适合于$^{221} $ fr的218-Kev gamma-ray发射,后者适合于440-Kev Gamma-ray排放$^{213} $ bi。这项工作包括$^{221} $ fr和$^{213} $ bi的$^{213} $ bi的编码孔图像,并注入了$^{225} $基于AC的放射性药物。这些结果是通过编码的光圈和康普顿成像可视化和量化小动物中的$^{225} $ ac女儿的首次演示,并用作将来放射性射精学研究的垫脚石。

Targeted alpha-particle therapy (TAT) has great promise as a cancer treatment. Arguably the most promising TAT radionuclide that has been proposed is $^{225}$Ac. The development of $^{225}$Ac-based radiopharmaceuticals has been hampered due to the lack of effective means to study the daughter redistribution of these agents in small animals at the preclinical stage. The ability to directly image the daughters, namely $^{221}$Fr and $^{213}$Bi, via their gamma-ray emissions would be a boon for preclinical studies. That said, conventional medical imaging modalities, including single photon emission computed tomography (SPECT) based on pinhole collimation, cannot be employed due to sensitivity limitations. As an alternative, we propose the use of both coded aperture and Compton imaging with the former modality suited to the 218-keV gamma-ray emission of $^{221}$Fr and the latter suited to the 440-keV gamma-ray emission of $^{213}$Bi. This work includes coded aperture images of $^{221}$Fr and Compton images of $^{213}$Bi in tumor-bearing mice injected with $^{225}$Ac-based radiopharmaceuticals. These results are the first demonstration of visualizing and quantifying the $^{225}$Ac daughters in small animals via coded aperture and Compton imaging and serve as a stepping stone for future radiopharmaceutical studies.

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