论文标题
最小模型，用于液态液相分离和化学反应性大分子混合物的老化
A minimal model for liquid-liquid phase separation and aging of chemically reactive macromolecular mixtures
论文作者
论文摘要
几种大分子物种的混合物会导致形成的高阶结构，这些结构通常显示出非理想的混合行为。在这项工作中，我们提出了第四纪系统的最小模型，该模型通过涉及两个大分子物种的化学反应来考虑复合物的形成。然后，该复合物可以与缓冲区分离，并随着时间的流逝而进一步过渡到类似凝胶状态的状态。首先，构建了捕获每个物种的体积分数和平衡时相的体积分数的三元相图。具体而言，我们研究了物理参数，例如化学计量系数，分子大小和相互作用参数如何影响LLP和衰老。最后，我们分析了两相系统的热力学稳定性，并确定了旋律区域，并概述了我们具有任意数量组件的反应性生物分子系统方法的概括。
Mixtures of several macromolecular species can lead to the formation of higher-order structures that often display non-ideal mixing behavior. In this work, we propose a minimal model of a quaternary system which considers the formation of a complex via a chemical reaction involving two macromolecular species; the complex may then phase separate from the buffer and undergo a further transition into a gel-like state over time. First, a ternary phase diagram that captures the volume fraction of each species and phases at equilibrium is constructed. Specifically, we investigate how physical parameters such as stoichiometric coefficients, molecular sizes and interaction parameters affect LLPS and aging. Finally, we analyze the thermodynamic stability of the two-phase system and identify the spinodal regions, and outline the generalization of our approach to reactive biomolecular systems with an arbitrary number of components.
