论文标题
生物细胞的电氢气活性
Electrohydraulic activity of biological cells
论文作者
论文摘要
在形态发生过程和维持稳态时，需要流体泵送和通过活组织产生的电流。这些流如何从细胞中的活性和被动离子转运中浮现出来。但是，流量和当前一代之间的相互作用尚不清楚。在这里，我们研究了由细胞离子泵送产生的电融合耦合。我们开发了跨活性细胞膜的流体和离子转运的一维连续模型。在弱电荷不平衡的极限中求解Nernst-Planck和Poisson方程，使我们能够得出模型的近似分析解决方案。这些近似值，与参数的生理相关状态的数值结果一致，使我们能够用实验可访问的参数来描述细胞和组织的电杂种活性。
Fluid pumping and the generation of electric current by living tissues are required during morphogenetic processes and for maintainance of homeostasis. How these flows emerge from active and passive ion transport in cells has been well established. However, the interplay between flow and current generation is not well understood. Here, we study the electro-hydraulic coupling that arises from cell ion pumping. We develop a one-dimensional continuum model of fluid and ion transport across active cell membranes. Solving the Nernst-Planck and Poisson equations in the limit of weak charge imbalance allows us to derive approximate analytical solutions of the model. These approximations, consistent with the numerical results in physiologically relevant regime of parameters, allow us to describe electro-hydraulic activity of cells and tissues in terms of experimentally accessible parameters.
