论文标题

在自动总肿瘤体积分段的指导下,头颈癌的自动总肿瘤体积分段的指导下,无复发的生存预测

Recurrence-free Survival Prediction under the Guidance of Automatic Gross Tumor Volume Segmentation for Head and Neck Cancers

论文作者

Wang, Kai, Li, Yunxiang, Dohopolski, Michael, Peng, Tao, Lu, Weiguo, Zhang, You, Wang, Jing

论文摘要

对于头颈癌(HNC)患者管理,自动总肿瘤体积(GTV)细分和准确的治疗前癌症复发预测对于帮助医生设计个性化管理计划至关重要,这有可能改善HNC患者的治疗结果和生活质量。在本文中,我们基于HNC患者的组合预处理正电子发射断层扫描/计算机发射断层扫描(PET/CT)扫描,开发了一种自动原发性肿瘤(GTVP)和淋巴结(GTVN)分割方法。我们从分段的肿瘤体积中提取了放射素学特征,并构建了多模式肿瘤复发生存率(RFS)预测模型,该模型融合了该预测,由单独的CT放射线学,PET放射线学和临床模型融合在一起。我们进行了5倍的交叉验证,以训练和评估MICCAI 2022头和颈部肿瘤分割和结果预测挑战(Hecktor)数据集的方法。 GTVP和GTVN分割的测试队列的集合预测分别为0.77和0.73,RFS预测的C-指数值为0.67。该代码可公开(https://github.com/wangkaiwan/hecktor-2022-airt)。我们团队的名字叫艾特。

For Head and Neck Cancers (HNC) patient management, automatic gross tumor volume (GTV) segmentation and accurate pre-treatment cancer recurrence prediction are of great importance to assist physicians in designing personalized management plans, which have the potential to improve the treatment outcome and quality of life for HNC patients. In this paper, we developed an automated primary tumor (GTVp) and lymph nodes (GTVn) segmentation method based on combined pre-treatment positron emission tomography/computed tomography (PET/CT) scans of HNC patients. We extracted radiomics features from the segmented tumor volume and constructed a multi-modality tumor recurrence-free survival (RFS) prediction model, which fused the prediction results from separate CT radiomics, PET radiomics, and clinical models. We performed 5-fold cross-validation to train and evaluate our methods on the MICCAI 2022 HEad and neCK TumOR segmentation and outcome prediction challenge (HECKTOR) dataset. The ensemble prediction results on the testing cohort achieved Dice scores of 0.77 and 0.73 for GTVp and GTVn segmentation, respectively, and a C-index value of 0.67 for RFS prediction. The code is publicly available (https://github.com/wangkaiwan/HECKTOR-2022-AIRT). Our team's name is AIRT.

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