论文标题
使用最小的复杂性构建块设计任意形状的自组装
Designing the self-assembly of arbitrary shapes using minimal complexity building blocks
论文作者
论文摘要
自组装多组分对象的设计空间范围从一个解决方案中,其中每个构建块都是独特的,其独特的构建块具有最小数量的不同构建块,这些构建块明确定义了目标结构。使用新型管道,我们探索了一组各种大小和复杂性结构的设计空间。为了了解不同溶液的含义,我们使用斑驳的粒子模拟分析了它们的组装动力学,并研究了不同构件的数量以及角度和空间公差对目标组件动力学和产量的相互作用的影响。我们表明,与每个构建块唯一的设计相比,具有最少不同块数量的最少不同块的资源解决方案通常也可以组装(或更快)。我们进一步使用我们的方法设计多种结构,其中不同目标结构之间共享构建块。最后,我们使用粗粒的DNA模拟来研究使用DNA纳米结构作为构建块的多组分形状的实现。
The design space for a self-assembled multicomponent objects ranges from a solution in which every building block is unique to one with the minimum number of distinct building blocks that unambiguously define the target structure. Using a novel pipeline, we explore the design spaces for a set of structures of various sizes and complexities. To understand the implications of the different solutions, we analyse their assembly dynamics using patchy particle simulations and study the influence of the number of distinct building blocks and the angular and spatial tolerances on their interactions on the kinetics and yield of the target assembly. We show that the resource-saving solution with minimum number of distinct blocks can often assemble just as well (or faster) than designs where each building block is unique. We further use our methods to design multifarious structures, where building blocks are shared between different target structures. Finally, we use coarse-grained DNA simulations to investigate the realisation of multicomponent shapes using DNA nanostructures as building blocks.