论文标题
一种新的用于研究带有体内数据的升主动脉流体动力学的公式
A novel formulation for the study of the ascending aortic fluid dynamics with in vivo data
论文作者
论文摘要
评估胸部主动脉血流动力学的数值模拟包括计算流体动力学（CFD）方法或流体结构相互作用（FSI）方法。尽管CFD通过应用刚性墙壁的简化来忽略沿心脏周期的动脉变形，而另一侧，FSI模拟需要对材料属性定义和高计算成本进行很多假设。这项研究的目的是根据径向基础功能（RBF）网状变形技术和瞬态模拟研究新策略的可行性，能够在心脏周期中引入主动脉几何学特异性变化。从医学图像开始，重建了心脏周期不同阶段的主动脉模型，并在模拟过程中通过适当激活增量RBF溶液获得了瞬态形状变形。就主要血液动力学参数而言，结果与两次对主动脉模型进行的CFD模拟的最小和最大体积进行了比较。我们实施的策略以高精度来应对心脏周期中的实际动脉变化，从而捕获了几何变化对流体动力学的影响，从而克服了标准FSI方法的复杂性。
Numerical simulations to evaluate thoracic aortic hemodynamics include a computational fluid dynamic (CFD) approach or fluid-structure interaction (FSI) approach. While CFD neglects the arterial deformation along the cardiac cycle by applying a rigid wall simplification, on the other side the FSI simulation requires a lot of assumptions for the material properties definition and high computational costs. The aim of this study is to investigate the feasibility of a new strategy, based on Radial Basis Functions (RBF) mesh morphing technique and transient simulations, able to introduce the patient-specific changes in aortic geometry during the cardiac cycle. Starting from medical images, aorta models at different phases of cardiac cycle were reconstructed and a transient shape deformation was obtained by proper activating incremental RBF solutions during the simulation process. The results, in terms of main hemodynamic parameters, were compared with two performed CFD simulations for the aortic model at minimum and maximum volume. Our implemented strategy copes the actual arterial variation during cardiac cycle with high accuracy, capturing the impact of geometrical variations on fluid dynamics, overcoming the complexity of a standard FSI approach.
