论文标题
SARS COV-2尖峰蛋白在各种功能化表面上的吸附与三角洲和Omicron变体的强感染性相关
Adsorption of SARS CoV-2 Spike Proteins on Various Functionalized Surfaces Correlates with the Strong Infectivity of Delta and Omicron Variants
论文作者
论文摘要
SARS COV-2病毒于2019年底出现，并迅速开发了几种突变的变体，特别是三角洲和OMICRON，这些变体在全球范围内表现出更高的感染性和不断升级的感染病例。该病毒的主要传播途径是通过人对人类接触和气溶胶的，但另一种可能的途径是与被SARS-COV-2污染的表面接触，通常表现出长期周期生存。在这里，我们比较了来自原始变体的S1和S2亚基的吸附能力与从三角洲和Omicron变体的S1亚基的吸附能力。结果清楚地表明，不同变体之间以及S1和S2亚基之间的吸附能力有显着差异。总体而言，我们的研究表明，尽管Omicron变体能够比Delta更成功地吸附，但两个变体都表现出比原始菌株增强的吸附能力。我们还检查了pH条件对S1亚基的吸附能力的影响，发现吸附在pH 7.4时最强，即生理pH值。这项研究的主要结论是，吸附能力与各种SARS COV-2变体的感染力之间存在很强的相关性。
The SARS CoV-2 virus emerged at the end of 2019 and rapidly developed several mutated variants, specifically the Delta and Omicron, which demonstrate higher infectivity and escalating infection cases worldwide. The dominant transmission pathway of this virus is via human-to-human contact and aerosols, but another possible route is through contact with surfaces contaminated with SARS-CoV-2, often exhibiting long-period survival. Here we compare the adsorption capacities of the S1 and S2 subunits of the spike (S) protein from the original variant to that of the S1 subunit from the Delta and Omicron variants. The results clearly show a significant difference in adsorption capacity between the different variants, as well as between the S1 and S2 subunits. Overall, our study demonstrates that while the Omicron variant is able to adsorb much more successfully than the Delta, both variants show enhanced adsorption capacity than the original strain. We also examined the influence of pH conditions on the adsorption ability of the S1 subunit and found that adsorption was strongest at pH 7.4, which is the physiological pH. The main conclusion of this study is that there is a strong correlation between the adsorption capacity and the infectivity of the various SARS CoV-2 variants.
