论文标题
细胞周期在集体细胞动力学中的作用
The role of the cell cycle in collective cell dynamics
论文作者
论文摘要
细胞在菌落或组织中共存。它们的行为受细胞间力与生化调节之间的相互作用控制。我们开发了一个简单的细胞周期模型，控制生长和分裂的基本调节网络，并将其与细胞集体内产生的物理力相结合。我们使用基于粒子的计算机模拟和连续理论分析了该模型。我们专注于限制在频道中的2D殖民地。这些发展在内部用静态细胞的分裂细胞的移动生长前端。这些前端的曲线和速度与底物摩擦和细胞周期参数无关，提供了一种可能在实验中测量此类参数的方法。
Cells coexist together in colonies or as tissues. Their behaviour is controlled by an interplay between intercellular forces and biochemical regulation. We develop a simple model of the cell cycle, the fundamental regulatory network controlling growth and division, and couple this to the physical forces arising within the cell collective. We analyse this model using both particle-based computer simulations and a continuum theory. We focus on 2D colonies confined in a channel. These develop moving growth fronts of dividing cells with quiescent cells in the interior. The profile and speed of these fronts are non-trivially related to the substrate friction and the cell cycle parameters, providing a possible approach to measure such parameters in experiments.
