论文标题
快速,自我监督,完全卷积的H&E染色图像的标准化
Fast, Self Supervised, Fully Convolutional Color Normalization of H&E Stained Images
论文作者
论文摘要
如果培训和测试集的数据分布不同,深度学习算法的性能会大大降低。由于染色方案,试剂品牌和技术人员习惯的变化,数字组织病理学图像中的颜色变化非常普遍。颜色变化会导致针对自动诊断系统在组织病理学中部署基于深度学习的解决方案的问题。先前提出的颜色归一化方法将一个小的贴剂视为标准化的参考,该参考会在分布源源图像上产生伪影。这些方法也很慢,因为大多数计算是在CPU而不是GPU上执行的。我们提出了一种颜色归一化技术,该技术在其自我监督训练和推理过程中很快。我们的方法基于轻巧的全趋化神经网络,可以轻松地将基于深度学习的管道作为预处理块附加到基于深度学习的管道上。对于CamelyOn17和Monuseg数据集上的分类和分割任务,所提出的方法比ART方法的状态更快,准确性更高。
Performance of deep learning algorithms decreases drastically if the data distributions of the training and testing sets are different. Due to variations in staining protocols, reagent brands, and habits of technicians, color variation in digital histopathology images is quite common. Color variation causes problems for the deployment of deep learning-based solutions for automatic diagnosis system in histopathology. Previously proposed color normalization methods consider a small patch as a reference for normalization, which creates artifacts on out-of-distribution source images. These methods are also slow as most of the computation is performed on CPUs instead of the GPUs. We propose a color normalization technique, which is fast during its self-supervised training as well as inference. Our method is based on a lightweight fully-convolutional neural network and can be easily attached to a deep learning-based pipeline as a pre-processing block. For classification and segmentation tasks on CAMELYON17 and MoNuSeg datasets respectively, the proposed method is faster and gives a greater increase in accuracy than the state of the art methods.