论文标题
nlMememodeling：用于动态系统非线性混合效应建模的Wolfram Mathematica软件包
NLMEModeling: A Wolfram Mathematica Package for Nonlinear Mixed Effects Modeling of Dynamical Systems
论文作者
论文摘要
在分析实验中几个实体的数据时，非线性混合效应建模是一种强大的工具。在本文中，我们提出了NLMememodeling，这是Wolfram Mathematica中混合效应建模的包装。 NLMememodeling支持动态系统的混合效应模型，其中基础动力学由普通或随机微分方程与灵活的观察误差模型相结合。此外，NLMememodeling是一个用户友好的软件包，具有用于模型验证，视觉预测检查和仿真功能的功能。该软件包是免费的，并为Wolfram Mathematica提供了灵活的附加组件。
Nonlinear mixed effects modeling is a powerful tool when analyzing data from several entities in an experiment. In this paper, we present NLMEModeling, a package for mixed effects modeling in Wolfram Mathematica. NLMEModeling supports mixed effects modeling of dynamical systems where the underlying dynamics are described by either ordinary or stochastic differential equations combined with a flexible observation error model. Moreover, NLMEModeling is a user-friendly package with functionality for model validation, visual predictive checks and simulation capabilities. The package is freely available and provides a flexible add-on to Wolfram Mathematica.
