论文标题

IPSC的数学建模简介

An introduction to the mathematical modelling of iPSCs

论文作者

Wadkin, Laura E, Orozco-Fuentes, Sirio, Neganova, Irina, Lako, Majlinda, Parker, Nicholas G, Shukurov, Anvar

论文摘要

本章的目的是传达数学建模作为对干细胞生物学有更深入了解的工具的重要性和实用性。我们介绍了关键的数学概念(随机步行理论,微分方程和基于代理的建模),这构成了当前诱导多能干细胞的当前描述的基础。我们希望鼓励生物学家与数学家之间进行有意义的对话,并强调这种跨学科方法的价值。

The aim of this chapter is to convey the importance and usefulness of mathematical modelling as a tool to achieve a deeper understanding of stem cell biology. We introduce key mathematical concepts (random walk theory, differential equations and agent-based modelling) which form the basis of current descriptions of induced pluripotent stem cells. We hope to encourage a meaningful dialogue between biologists and mathematicians and highlight the value of such an interdisciplinary approach.

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