论文标题
纳米级动态读数是使用自由基与纳米座中的氮相位中心结合的自由基工艺的动态读数
Nanoscale Dynamic Readout of a Chemical Redox Process Using Radicals Coupled with Nitrogen-Vacancy Centers in Nanodiamonds
论文作者
论文摘要
生物相容性的纳米级探针，用于对与其（BIO）化学转化相关的顺磁性物种和分子的敏感检测，将为更好地理解细胞氧化还原过程提供理想的工具。在这里，我们描述了一种基于量子传感技术的分析工具。我们在NDS中存在磁氧化氨基（NDS）中磁性耦合带负电荷的氮气胶囊（NV）中心，并存在于NDS的生物启动聚合物涂层中。我们证明了NV中心的T1自旋松弛时间非常敏感，硝基氧化物自由基的数量每ND的分辨率下降到约10旋转（检测约为$ 10^-23 $ sol的局部体积）。该检测基于对根部附着的T1缩短，我们提出了一个描述这种现象的理论模型。我们进一步显示，这种胶体稳定的水溶性系统可以动态使用，用于在环境条件下在水性环境下在ND表面附近发生的氧化还原化学过程（氧化）的时空读数。
Biocompatible nanoscale probes for sensitive detection of paramagnetic species and molecules associated with their (bio)chemical transformations would provide a desirable tool for a better understanding of cellular redox processes. Here, we describe an analytical tool based on quantum sensing techniques. We magnetically coupled negatively charged nitrogen-vacancy (NV) centers in nanodiamonds (NDs) with nitroxide radicals present in a bioinert polymer coating of the NDs. We demonstrated that the T1 spin relaxation time of NV centers is very sensitive to the number of nitroxide radicals, with a resolution down to ~10 spins per ND (detection of approximately $ 10^-23 $ mol in a localized volume). The detection is based on T1 shortening upon the radical attachment and we propose a theoretical model describing this phenomenon. We further show this colloidally stable, water-soluble system can be used dynamically for spatiotemporal readout of a redox chemical process (oxidation of ascorbic acid) occurring near the ND surface in an aqueous environment under ambient conditions.
