论文标题
通过动态突变算法的散射介质的自适应光学聚焦
Adaptive optical focusing through perturbed scattering media with dynamic mutation algorithm
论文作者
论文摘要
通过/内部散射介质(如多模纤维和生物组织)的光聚焦对生物医学的影响很大,但由于光的强散射性质而被认为是具有挑战性的。以前,从迭代的光波前塑形中受益,已经取得了有希望的进步,深层组织高分辨率光聚焦成为可能。大多数迭代算法都可以克服噪声扰动,但无法有效地适应噪声,例如突然强烈的扰动。重大反复相关的介质通常需要重新挑选,因为这些算法严重依赖于先前迭代中的优化。这种无效性可能是由于缺乏可以根据同时测量的光学焦点来衡量即时波前与最佳补偿的偏差的度量。在这项研究中,从理论上证明并通过实验验证了二元振幅调制的平方规则,该规则将测得的聚焦性能与优化波前的误差直接相关。使用这个简单的规则,可以量化空间照明调制器上有多少像素错误地调节波前的介质或整个系统的即时状态。作为应用的一个示例,我们提出了一种新型算法,动态突变算法,通过探测优化在理论上最佳的程度,具有对扰动的高适应性。当对介质的扰动导致焦点性能的显着下降时,散射光的焦点的减少可以有效地恢复,由于其固有的强大依赖性对先前的优化,因此无法实现现有算法。随着进一步的改进,这项研究可能会在稳定的散射环境中提高或激发许多应用,例如高分辨率成像和刺激。
Optical focusing through/inside scattering media, like multimode fiber and biological tissues, has significant impact in biomedicine yet considered challenging due to strong scattering nature of light. Previously, promising progress has been made, benefiting from the iterative optical wavefront shaping, with which deep-tissue high-resolution optical focusing becomes possible. Most of iterative algorithms can overcome noise perturbations but fail to effectively adapt beyond the noise, e.g. sudden strong perturbations. Re-optimizations are usually needed for significant decorrelated medium since these algorithms heavily rely on the optimization in the previous iterations. Such ineffectiveness is probably due to the absence of a metric that can gauge the deviation of the instant wavefront from the optimum compensation based on the concurrently measured optical focusing. In this study, a square rule of binary-amplitude modulation, directly relating the measured focusing performance with the error in the optimized wavefront, is theoretically proved and experimentally validated. With this simple rule, it is feasible to quantify how many pixels on the spatial light modulator incorrectly modulate the wavefront for the instant status of the medium or the whole system. As an example of application, we propose a novel algorithm, dynamic mutation algorithm, with high adaptability against perturbations by probing how far the optimization has gone toward the theoretically optimum. The diminished focus of scattered light can be effectively recovered when perturbations to the medium cause significant drop of the focusing performance, which no existing algorithms can achieve due to their inherent strong dependence on previous optimizations. With further improvement, this study may boost or inspire many applications, like high-resolution imaging and stimulation, in instable scattering environments.