论文标题
用于骨骼肌细胞对齐和光刺激的聚合物混合底物
A Polymer Blend Substrate for Skeletal Muscle Cells Alignment and Photostimulation
论文作者
论文摘要
转向细胞生长的底物工程是现代生物技术领域的广泛且建立了良好的研究领域。在这里，我们介绍了一种微加工技术，以对惰性，透明的聚合物基质进行对光活性聚合物混合。我们证明所获得的支架结合了与光刺激活细胞相一致的能力。这项技术可以打开新的和有希望的应用程序，尤其是在需要细胞对齐的情况下触发特定的生物学功能，例如外部刺激后产生强大而有效的肌肉收缩。
Substrate engineering for steering cell growth is a wide and well-established area of research in the field of modern biotechnology. Here we introduce a micromachining technique to pattern an inert, transparent polymer matrix blended with a photoactive polymer. We demonstrate that the obtained scaffold combines the capability to align with that to photostimulate living cells. This technology can open up new and promising applications, especially where cell alignment is required to trigger specific biological functions, e.g. generate powerful and efficient muscle contractions following an external stimulus.
