论文标题
通过频率特征的成人头皮脑电图中病理减慢的自动分类的多中心验证研究
Multi-center validation study of automated classification of pathological slowing in adult scalp electroencephalograms via frequency features
论文作者
论文摘要
广泛研究了脑电图(EEG)的病理放缓(EEG)以诊断神经系统疾病。当前,放缓检测的黄金标准是专家对脑电图的目视检查,这是耗时且主观的。为了解决这些问题,我们提出了三种自动化方法来检测EEG的放缓:基于阈值的检测系统(TDS),基于浅层学习的检测系统(SLDS)和基于深度学习的检测系统(DLDS)。这些系统在通道,段和脑电图级上进行评估。 TDS,SLD和DLDS通过检测单个通道的放缓来执行预测,这些检测是在直方图中排列的,以检测段和EEG级别的放缓。我们通过来自美国,新加坡和印度的四个数据集上的四个数据集上的跨受试者(LOSO)交叉验证(CV)和一家机构外(LOIO)CV评估系统。 DLDS取得了最佳的总体结果:LOIO CV平均平衡精度(BAC)为71.9%,75.5%和82.0%,在通道,分段和EEG级别和LOSO CV平均BAC为73.6%,77.2%和77.2%和81.8%的频道,sember-sev-emeg-和Eeg eeg level。渠道和细分市场级别的性能与72.4%和82%的专家的评估者协议(IRA)相当。 DLDS可以在4秒内处理30分钟的脑电图,并可以部署以帮助临床医生解释脑电图。
Pathological slowing in the electroencephalogram (EEG) is widely investigated for the diagnosis of neurological disorders. Currently, the gold standard for slowing detection is the visual inspection of the EEG by experts, which is time-consuming and subjective. To address those issues, we propose three automated approaches to detect slowing in EEG: Threshold-based Detecting System (TDS), Shallow Learning-based Detecting System (SLDS), and Deep Learning-based Detecting System (DLDS). These systems are evaluated on channel-, segment- and EEG-level. The TDS, SLDS, and DLDS performs prediction via detecting slowing at individual channels, and those detections are arranged in histograms for detection of slowing at the segment- and EEG-level. We evaluate the systems through Leave-One-Subject-Out (LOSO) cross-validation (CV) and Leave-One-Institution-Out (LOIO) CV on four datasets from the US, Singapore, and India. The DLDS achieved the best overall results: LOIO CV mean balanced accuracy (BAC) of 71.9%, 75.5%, and 82.0% at channel-, segment- and EEG-level, and LOSO CV mean BAC of 73.6%, 77.2%, and 81.8% at channel-, segment-, and EEG-level. The channel- and segment-level performance is comparable to the intra-rater agreement (IRA) of an expert of 72.4% and 82%. The DLDS can process a 30-minutes EEG in 4 seconds and can be deployed to assist clinicians in interpreting EEGs.