论文标题
在〜1.1米的二氧化杂介质中朝着非接触式葡萄糖传感
Towards Non-Contact Glucose Sensing in Aqueous Turbid Medium at ~1.1 Meters Distance
论文作者
论文摘要
这项工作证明了一种非接触式弥散反射方法，其工作距离为〜1.1米，具有葡萄糖感应的潜力。根据中心释放区域检测（CIAD）几何形状，开发了1.1-1.3微米以上的非接触式扩散反射率。通过独立改变收集几何形状的大小以及培养基的散射和吸收特性，使用幻像检查了CIAD几何形状中扩散反射的建模响应。当应用于含有葡萄糖控制溶液的水性混浊培养基，其累积体积在三个数量级上有所不同时，可以观察到在有效的葡萄糖中型组成的四个条件下，在有效的葡萄糖浓度中有不同的葡萄糖中型组成的介质吸收/散生特性的函数，预期的是弥漫性反射率的线性关系。具有相同光学特性的宿主培养基中葡萄糖的累积高达17.8mg/dL和8.9mg/dl，分别导致线性回归斜率分别为0.0032和0.0030。在水性宿主培养基中，葡萄糖的累积高达17.8mg/dL，在散射降低的散射特性中有两个折叠的累积导致线性回归斜率在0.0032和0.0019之间有所不同。所有情况的R^2值均大于0.987。为此工作获得了临时专利（US＃63/053,004）。
This work demonstrates a non-contact diffuse reflectance approach with a working distance of ~1.1 meters for the potential of glucose sensing. Non-contact diffuse reflectance over 1.1-1.3 micrometers was developed according to a center-illumination-area-detection (CIAD) geometry. The modeled response of diffuse reflectance in the CIAD geometry was examined with phantoms by altering independently the size of the collection geometry and the reduced scattering and absorption properties of the medium. When applied to aqueous turbid medium containing glucose control solutions with the cumulative volume varying over three orders of magnitude, a linear relationship expected for the diffuse reflectance as a function of the medium absorption/reduced-scattering property was observed for four conditions of the glucose-medium composition that differed either in the effective glucose concentration or the host medium scattering property. The cumulation of glucose up to 17.8mg/dL and 8.9mg/dL in the host medium having the same optical properties resulted in linear regression slopes of 0.0032 and 0.0030, respectively. The cumulation of the glucose up to 17.8mg/dL in an aqueous host medium that differed two folds in the reduced scattering property caused the linear regression slope to differ between 0.0032 and 0.0019. The R^2 values of all cases were all greater than 0.987. A provisional patent (US#63/053,004) has been obtained for this work.
