论文标题
聚集了具有依赖聚集的抗菌活性的片状等离子体纳米颗粒
Assembling patchy plasmonic nanoparticles with aggregation-dependent antibacterial activity
论文作者
论文摘要
我们基于斑块等离子胶体的自限组装实现抗菌纳米材料，该组合是通过吸附到金纳米颗粒上获得的。在数百个纳米内选择组件大小的可能性使得在从可见到近红外的各种频率中调整其光学响应。我们还证明了催化活性的聚集依赖性调节，这导致了适当大小的组件的抗菌性能增强。这种纳米材料的结构，光学特性和生物学活性的总体控制铺平了新型抗菌纳米因素的道路，并在治疗多药物抗性细菌方面有很有希望的应用。
We realise an antibacterial nanomaterial based on the self-limited assembly of patchy plasmonic colloids, obtained by adsorption of lysozyme to gold nanoparticles. The possibility of selecting the size of the assemblies within several hundred nanometres allows for tuning their optical response in a wide range of frequencies from visible to near infrared. We also demonstrate an aggregation-dependent modulation of the catalytic activity, which results in an enhancement of the antibacterial performances for assemblies of the proper size. The gained overall control on structure, optical properties and biological activity of such nanomaterial paves the way for the development of novel antibacterial nanozymes with promising applications in treating multi drug resistant bacteria.
