论文标题
混合运动合奏的流变学
Rheology of mixed motor ensembles
论文作者
论文摘要
生物细胞的流变学不仅取决于其细胞骨架网络，还取决于交联和收缩的分子电机。最近发现，非肌肉细胞中肌球蛋白II分子电动机的组件是快速和慢速运动变体的混合物。使用计算机模拟和肌球蛋白II电动机的Crossbridge模型的分析平均场理论，我们在这里表明，这种电动机合奏有效地表现为主动的Maxwell元素。我们计算存储和损耗模量是模型参数的函数，并表明流变特性从粘性到弹性越过，因为一个人会增加慢速与快速电动机的比率。这表明细胞通过调节其肌球蛋白组件的组成来调整其机械性能。
The rheology of biological cells is not only determined by their cytoskeletal networks, but also by the molecular motors that crosslink and contract them. Recently it has been found that the assemblies of myosin II molecular motors in non-muscle cells are mixtures of fast and slow motor variants. Using computer simulations and an analytical mean field theory of a crossbridge model for myosin II motors, here we show that such motor ensembles effectively behave as active Maxwell elements. We calculate storage and loss moduli as a function of the model parameters and show that the rheological properties cross over from viscous to elastic as one increases the ratio of slow to fast motors. This suggests that cells tune their mechanical properties by regulating the composition of their myosin assemblies.
