论文标题

绘制欧洲粒子放射生物学的未来:Inspire项目

Mapping the Future of Particle Radiobiology in Europe: The INSPIRE Project

论文作者

Henthorn, N. T., Sokol, O., Durante, M., De Marzi, L., Pouzoulet, F., Miszczyk, J., Olko, P., Brandenburg, S., van Goethem, M-J., Barazzuol, L., Tambas, M., Langendijk, J. A., Davidkova, M., Vondravcek, V., Bodenstein, E., Pawelke, J., Lomax, A., Weber, D. C., Dasu, A., Stenerlow, B., Poulsen, P. R., Sorensen, B. S., Grau, C., Sitarz, M. K., Heuskin, A-C, Lucas, S., Warmenhoven, J. W., Merchant, M. J., Mackay, R. I., Kirkby, K. J.

论文摘要

粒子疗法是全球范围内增长的癌症治疗方式。但是,考虑到颗粒和光子之间的生物学反应差异,仍然存在许多未解决的问题。这些问题以及对生物学机制的探测需要实验研究。创建了Proton International Research(INSPIRE)项目的基础设施,目的是为欧洲研究提供基础设施,统一欧洲质子和离子疗法的研究工作,并促进信息和资源的共享。这项工作突出了激发伴侣的放射生物学能力,提供了物理学(可用的粒子类型和能量),生物学(样品制备和辐照后分析)和研究人员的访问(申请光束时间的过程)。此处报告的信息收集旨在为欧洲和全球的研究人员提供为其研究需求选择最佳中心所需的工具。我们还强调了能力冗余的领域,并建议未来投资的领域。

Particle therapy is a growing cancer treatment modality worldwide. However, there still remains a number of unanswered questions considering differences in the biological response between particles and photons. These questions, and probing of biological mechanisms in general, necessitate experimental investigation. The Infrastructure in Proton International Research (INSPIRE) project was created to provide an infrastructure for European research, unify research efforts on the topic of proton and ion therapy across Europe, and to facilitate the sharing of information and resources. This work highlights the radiobiological capabilities of the INSPIRE partners, providing details of physics (available particle types and energies), biology (sample preparation and post-irradiation analysis), and researcher access (the process of applying for beam time). The collection of information reported here is designed to provide researchers both in Europe and worldwide with the tools required to select the optimal center for their research needs. We also highlight areas of redundancy in capabilities and suggest areas for future investment.

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