论文标题
最佳进化决策以存储免疫记忆
Optimal evolutionary decision-making to store immune memory
论文作者
论文摘要
自适应免疫系统提供了各种分子，可以针对多种病原体进行特定的反应。记忆是自适应免疫的关键特征，它允许生物体对重新感染更容易做出反应。然而，记忆细胞的分化仍然是最知名的细胞命运决定之一。在这里，我们介绍了一个数学框架，以表征最佳的策略来存储记忆，以最大程度地利用生物体的生命周期中免疫反应的实用性。我们表明，应积极调节记忆产生，以在免疫受体的亲和力和交叉反应之间平衡，以防止病原体的有效保护。此外，我们预测记忆的特异性应取决于生物体的寿命，而寿命较短的生物具有较少的致病性相遇，应存储更多的交叉反应记忆。我们的框架提供了一个基线，以根据生物体与病原体的共同进化史来评估免疫记忆的功效。
The adaptive immune system provides a diverse set of molecules that can mount specific responses against a multitude of pathogens. Memory is a key feature of adaptive immunity, which allows organisms to respond more readily upon re-infections. However, differentiation of memory cells is still one of the least understood cell fate decisions. Here, we introduce a mathematical framework to characterize optimal strategies to store memory to maximize the utility of immune response over an organism's lifetime. We show that memory production should be actively regulated to balance between affinity and cross-reactivity of immune receptors for an effective protection against evolving pathogens. Moreover, we predict that specificity of memory should depend on the organism's lifespan, and shorter-lived organisms with fewer pathogenic encounters should store more cross-reactive memory. Our framework provides a baseline to gauge the efficacy of immune memory in light of an organism's coevolutionary history with pathogens.
