论文标题
软分子分子限制
Soft macromolecular confinement
论文作者
论文摘要
我们使用模拟和连续理论研究了软脂质小管内部狭窄的半串联链的平衡形状和形状转化。变形的管状形状和链构象取决于其弯曲模量的相对大小。我们通过计算探测小长度的聚合物特性的统计量来表征折叠的大分子形状，并向环形线圈过渡报告刚性链的巨大。使用弹性理论计算的变形管状形状与模拟一致。结合散射研究，我们的工作可以提供对软结构中基因封装的机械理解。
We study equilibrium shapes and shape transformations of a confined semiflexible chain inside a soft lipid tubule using simulations and continuum theories. The deformed tubular shapes and chain conformations depend on the relative magnitude of their bending moduli. We characterise the collapsed macromolecular shapes by computing statistical quantities that probe the polymer properties at small length scales and report a prolate to toroidal coil transition for stiff chains. Deformed tubular shapes, calculated using elastic theories, agree with simulations. In conjunction with scattering studies, our work may provide a mechanistic understanding of gene encapsulation in soft structures.
