论文标题
基于康普顿X射线散射的新成像技术
A new imaging technology based on Compton X-ray scattering
论文作者
论文摘要
我们描述了针对高能X射线光子的新型X射线检测器的可行实现，具有较大的实体角度覆盖范围，最适合检测康普顿X射线散射光子。该设备由在大气压下填充XENON的20厘米厚度敏感体积组成。当康普顿冰片光子与氙气相互作用时，释放的光电子会产生次级电离的云，这些云是使用定制的多孔丙烯酸结构中产生的电致发光成像的。可以通过在连续读数模式下处理所得图像来实现逐个光子计数。基于GEANT4模拟，通过考虑逼真的探测器设计和响应，我们表明，可以处理光子速率至少$ 10^{11} $ pH/s样品（$ 5〜μ $ M $ M $ M $ M $ M $ M水等效单元），受到光电在气体中的空间扩散的限制。说明说明，如果利用玫瑰标准并假设定理的剂量分配，我们会在大约24〜h中以36〜nm的分辨率在其本机环境中允许在本机环境中获得$ 5〜μ $ m大小未固定的细胞的3D图像。
We describe a feasible implementation of a novel X-ray detector for highly energetic x-ray photons with a large solid angle coverage, optimal for the detection of Compton x-ray scattered photons. The device consists of a 20~cm-thick sensitive volume filled with xenon at atmospheric pressure. When the Compton-scattered photons interact with the xenon, the released photoelectrons create clouds of secondary ionization, which are imaged using the electroluminescence produced in a custom-made multi-hole acrylic structure. Photon-by-photon counting can be achieved by processing the resulting image, taken in a continuous readout mode. Based on Geant4 simulations, by considering a realistic detector design and response, we show that photon rates up to at least $10^{11}$ ph/s on-sample ($5~μ$m water-equivalent cell) can be processed, limited by the spatial diffusion of the photoelectrons in the gas. Illustratively, if making use of the Rose criterion and assuming the dose partitioning theorem, we show how such a detector would allow obtaining 3d images of $5~μ$m-size unstained cells in their native environment in about 24~h, with a resolution of 36~nm.
