论文标题
通过高级信号处理检测细胞微功能
Detection of cellular micromotion by advanced signal processing
论文作者
论文摘要
已经提出了细胞微功能 - 细胞膜在纳米微米尺度上的微小运动 - 已被提议作为细胞间信号转导的途径，并作为对神经活动的无标签代理信号。在这里，我们利用了一些最新的信号处理方法来检测未标记细胞的视频记录中的这种微功能。我们的调查包括视频信号的光谱过滤，匹配的过滤，以及作用于像素时域数据和整个录制的1D和3D卷积神经网络。
Cellular micromotion - a tiny movement of cell membranes on the nanometer-micrometer scale - has been proposed as a pathway for inter-cellular signal transduction and as a label-free proxy signal to neural activity. Here we harness several recent approaches of signal processing to detect such micromotion in video recordings of unlabeled cells. Our survey includes spectral filtering of the video signal, matched filtering, as well as 1D and 3D convolutional neural networks acting on pixel-wise time-domain data and a whole recording respectively.
