论文标题
年龄挑战:前节光学相干断层扫描中的角度闭合青光眼评估
AGE Challenge: Angle Closure Glaucoma Evaluation in Anterior Segment Optical Coherence Tomography
论文作者
论文摘要
角度闭合青光眼(ACG)是一种比开开性青光眼更具侵略性疾病,在该疾病中,前腔角的异常解剖结构(ACA)可能导致眼内压力升高,并逐渐导致青光眼的光学神经性神经病,并最终导致视觉障碍和失明。前段光学相干断层扫描(AS-OCT)成像提供了一种快速,无接触式的方法,可区分角度闭合从空角闭合。尽管已经开发了许多医学图像分析算法用于青光眼诊断,但只有少数研究集中于AS-OCT成像。特别是,没有公共AS-OCT数据集可用于以统一的方式评估现有方法,这限制了自动化技术开发以进行角度闭合检测和评估。为了解决这个问题,我们组织了与2019年Miccai合作举行的角度闭合青光眼评估挑战(年龄)。年龄挑战包括两项任务:巩膜刺激性定位和角度闭合分类。在这一挑战中,我们发布了来自199名患者的4800个注释AS-OCT图像的大型数据集,并提出了一个评估框架,以基准测试和比较不同的模型。在年龄挑战期间,超过200个团队在线注册,并提交了1100多个结果以进行在线评估。最后,八支球队参加了现场挑战。在本文中,我们总结了这八种现场挑战方法,并分析了两项任务的相应结果。我们进一步讨论局限性和未来的方向。在年龄挑战中,表现最佳的方法的平均欧几里得距离为10像素(10UM),而在巩膜刺激性的定位中,在角度闭合分类的任务中,所有算法都达到了令人满意的性能,并且获得了两个最佳的精度为100%。
Angle closure glaucoma (ACG) is a more aggressive disease than open-angle glaucoma, where the abnormal anatomical structures of the anterior chamber angle (ACA) may cause an elevated intraocular pressure and gradually lead to glaucomatous optic neuropathy and eventually to visual impairment and blindness. Anterior Segment Optical Coherence Tomography (AS-OCT) imaging provides a fast and contactless way to discriminate angle closure from open angle. Although many medical image analysis algorithms have been developed for glaucoma diagnosis, only a few studies have focused on AS-OCT imaging. In particular, there is no public AS-OCT dataset available for evaluating the existing methods in a uniform way, which limits progress in the development of automated techniques for angle closure detection and assessment. To address this, we organized the Angle closure Glaucoma Evaluation challenge (AGE), held in conjunction with MICCAI 2019. The AGE challenge consisted of two tasks: scleral spur localization and angle closure classification. For this challenge, we released a large dataset of 4800 annotated AS-OCT images from 199 patients, and also proposed an evaluation framework to benchmark and compare different models. During the AGE challenge, over 200 teams registered online, and more than 1100 results were submitted for online evaluation. Finally, eight teams participated in the onsite challenge. In this paper, we summarize these eight onsite challenge methods and analyze their corresponding results for the two tasks. We further discuss limitations and future directions. In the AGE challenge, the top-performing approach had an average Euclidean Distance of 10 pixels (10um) in scleral spur localization, while in the task of angle closure classification, all the algorithms achieved satisfactory performances, with two best obtaining an accuracy rate of 100%.