论文标题
经过当前状态数据的修改COX回归
Modified Cox regression with current status data
论文作者
论文摘要
在生存分析中,并不总是观察到正在研究的寿命。在某些应用中,对于某些人来说,寿命的价值仅比某些随机持续时间更小或更大。该框架代表了寿命仅左或右随机审查的标准情况的扩展。我们考虑了独立观察单元还包括一些协变量的情况,我们提出了两个半参数回归模型。新模型将标准COX比例危害模型扩展到更复杂的审查机制的情况。但是,与Cox的模型一样,在这两个模型中,非参数基线危害函数仍然可以表示为观测值分布的明确功能。这允许将有限维参数的估计器定义为可能性型标准的最大值,这是数据的明确函数。鉴于对有限维参数的估计值,基线累积危害函数的估计很简单。
In survival analysis, the lifetime under study is not always observed. In certain applications, for some individuals, the value of the lifetime is only known to be smaller or larger than some random duration. This framework represent an extension of standard situations where the lifetime is only left or only right randomly censored. We consider the case where the independent observation units include also some covariates, and we propose two semiparametric regression models. The new models extend the standard Cox proportional hazard model to the situation of a more complex censoring mechanism. However, like in Cox's model, in both models the nonparametric baseline hazard function still could be expressed as an explicit functional of the distribution of the observations. This allows to define the estimator of the finite-dimensional parameters as the maximum of a likelihood-type criterion which is an explicit function of the data. Given an estimate of the finite-dimensional parameter, the estimation of the baseline cumulative hazard function is straightforward.